• ​​​Casella LG, Weiss A, Perez-Rueda E, Ibarra JA, Shaw LN. Towards the Complete Proteinaceous Regulome of Acinetobacter baumannii. Microbial Genomics (mGen). Accepted. doi: 10.1099/mgen.0.000107


  • Tu N, Carroll RK, Weiss A, Shaw LN, Nicolas G, Thomas S, Lima A, Anderson B. A family of genus-specific RNAs in tandem with DNA-binding proteins control expression of the badA major virulence factor gene in Bartonella henselae. MicrobiologyOpen. Accepted. doi:10.1002/mbo3.420


  • Weiss A, Moore BD, Tremblay MHJ, Chaput D, Kremer A, Shaw LN. (2017). The Ω Subunit Governs RNA Polymerase Stability and Transcriptional Specificity in Staphylococcus aureus. Journal of Bacteriology. 199(2): e00459-16.


  • Wiemels A, Cech S, Meyer N, Weiss A, Parks A, Shaw LN, Carroll RK. (2017). An intracellular peptidyl-prolyl cis/trans isomerase (PPIase) is required for folding and activity of the Staphylococcus aureus secreted virulence factor nuclease. Journal of Bacteriology. 199(1): e00453-16.


  • Mashruwala AA, Roberts C, Bhatt S, May KL, Carroll RK, Shaw LN, Boyd JM. (2016). The conditional essentiality of the Staphylococcus aureus DUF59 domain protein SufT demonstrates that cellular demand for the products of iron-sulfur (FeS) enzymes is one factor governing the specificity of FeS assembly factors for FeS protein maturation. Molecular Microbiology. 102(6): 1099-1119.


  • Weiss A, Fleeman RM, Shaw LN. (2016). Exposing the Unique Connection Between Metabolism and Virulence in Staphylococcus aureus. Cell Chemical Biology. 23(11): 1317-1319.


  • ​Grosser M, Weiss A, Shaw LN, Richardson A. (2016). Regulatory requirements for Staphylococcus aureus nitric oxide resistance. Journal of Bacteriology. 198(15): 2043-2055.


  • Weiss A, Broach WH, Shaw LN. (2016). Adaptation of the Staphylococcus aureus Transcriptome to Stationary Phase Growth. Pathogens & Disease. 74(5): doi: 10.1093/femspd/ftw046


  • Broach WH, Weiss A, Shaw LN. (2016).Transcriptomic Analysis of Staphylococcal sRNAs: Insights into Species Specific Adaption and the Evolution of Pathogenesis. Microbial Genomics (mGen). 2(7):doi:10.1099/mgen.0.000065


  • Balasubramanian D, Ohneck EA, Lim-Chapman J, Weiss A, Kim MK, Reyes-Robles T, Shaw LN, Lun DS, Ueberheide B, Shopsin B, Torres VJ. (2016). Staphylococcus aureus coordinates leukocidins expression and pathogenesis by sensing metabolic fluxes via RpiRC. mBio. 21;7(3). pii: e00818-16.


  • Carroll RK, Weiss A, Mogen AB, Rice KC, Shaw LN. (2016). Genome wide annotation, identification and global transcriptomic analysis of regulatory or small RNA gene expression in Staphylococcus aureus. mBio. 7(1). e01990-15.


  • Weiss A, Broach WH, Lee MC, Shaw LN. (2016). Towards the Complete Small RNome of Acinetobacter baumannii. Microbial Genomics (mGen). 2(3):10.1099/mgen.0.00004


  • Lyons ST, Wright CA, Krute CN, Rivera FE, Carroll RK, Shaw LN. (2016). Confirming Sterility of an Autoclaved Infected Femoral Component for Use in an Articulated Antibiotic Knee Spacer: A Pilot Study. Journal of Arthroplasty. 31(1): 245-249.


  • Carroll RK, Weiss A & Shaw LN. (2016). RNA-sequencing of Staphylococcus aureus messenger RNA. Methods in Molecular Biology. 1373: 131-141.


  • Morgan J, Carroll R, Harro C, Vendura K, Shaw LN, Riordan, JT. (2015). Global regulator of virulence A (GrvA) coordinates expression of discrete pathogenic mechanisms in enterohemorrhagic Escherichia coli through interactions with GadW-GadE. Journal of Bacteriology. 2(198): 394-409.


  • Weiss A and Shaw LN. (2015). Small Things Considered: The Small Accessory Subunits of RNA Polymerase in Gram-positive Bacteria. FEMS Microbiology Reviews. 39(4): 541-554.


  • Krute CK, Bell-Temin H, Miller HK, Rivera FE, Weiss A, Stevens SM, Shaw LN. (2015). The Membrane Protein PrsS Mimics σS in Protecting Staphylococcus aureus Against Cell Wall-Targeting Antibiotics and DNA Damaging Agents. Microbiology. 161(5): 1136 – 1148.


  • ​Koziel J, Chmiest D, Kmiecik K, Mizgalska D, Maciag-Gudowska, Shaw LN, Potempa J. (2015). The Janus Face of α-Toxin: A Potent Mediator of Cytoprotection in Staphylococci Infected Macrophages. Journal of Innate Immunity. 7(2): 187-198.


  • Krute CK, Carroll RK, Rivera FE, Weiss A, Young RM, Shilling A, Botlani M, Varma S, Baker BJ, Shaw LN. (2015). The Disruption of Prenylation Leads to Pleiotropic Rearrangements in Cellular Behaviour in Staphylococcus aureus. Molecular Microbiology. 95(5): 819-832.


  • Burda WN, Miller HK, Krute CK, Leighton SL, Carroll RK, Shaw LN. (2014). Investigating the Genetic Regulation of the ECF-Sigma Factor σS in Staphylococcus aureus. BMC Microbiology. 14(1): 280.


  • Sapp AM, Mogen AB, Almand EA, Rivera FE, Shaw LN, Richardson AR, Rice KC. (2014). Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus. PLoS ONE. 2;9(9):e108868.


  • Mitra A, Fay P, Vendura KW, Alla Z, Carroll RK, Shaw LN, Riordan JT. (2014). σN-dependent control of acid resistance and the locus of enterocyte effacement in enterohemorrhagic Escherichia coli is activated by acetyl phosphate in a manner requiring flagellar regulator FlhDC and the σS antagonist FliZ. MicrobiologyOpen. 3(4): 497-512.


  • Carroll RK, Rivera FE, Cavaco, CK, Johnson GM, Martin D, Shaw LN. (2014). The lone S41 family C-terminal processing protease in Staphylococcus aureus is localized to the cell wall and contributes to virulence. Microbiology. 160(8): 1737-1748.


  • Weiss A, Ibarra JA, Paoletti J, Carroll RK, Shaw LN. (2014). The δ Subunit of RNA Polymerase Guides Promoter Selectivity and Virulence in Staphylococcus aureus. Infection and Immunity. 82(4): 1424-1435.


  • Jusko M, Potempa J, Kantyka T, Bielecka E, Miller HK, Kulczycka M, Garred P, Shaw LN, Blom AM. (2014). Staphylococcal proteases aid evasion of the human complement system. Journal of Innate Immunity. 6(1): 31-46.


  • Mootz JM, Malone CL, Shaw LN, Horswill AR. (2013). Staphopains modulate Staphylococcus aureus biofilm integrity. Infection and Immunity. 81(9): 3227-3238.


  • Kenny JG, Moran J, Kolar SL, Ulanov A, Zhong L, Shaw LN, Josefsson E, Horsburgh MJ. (2013). Mannitol Utilisation is Required for Protection of Staphylococcus aureus from Human Skin Antimicrobial Fatty Acids. PLoS ONE. 8(7): e67698.


  • Carroll RK, Burda WN, Roberts JC, Peak KK, Cannons AC, Shaw LN. (2013). Draft genome of strain CBD-635: a Methicillin Resistant Staphylococcus aureus USA100 isolate. Genome Announcements. 1(4): e00491-13.


  • Carroll RK, Veillard F, Gagne D, Lindenmuth J, Poreba M, Drag M, Potempa J, Shaw LN. (2013). The Staphylococcus aureus leucine aminopeptidase is localized to the bacterial cytosol and demonstrates a broad substrate range that extends beyond leucine. Biol Chem. 394(6): 791-803.


  • Ibarra JA, Perez-Rueda E, Carroll RK, Shaw LN. (2013). Global Analysis of Transcriptional Regulators in Staphylococcus aureus. BMC Genomics. 14(1):126.


  • Kolar SL, Ibarra AJ, Rivera FE, Mootz JM, Davenport JE, Stevens SM, Horswill AR, Shaw LN. (2013). Extracellular Proteases are Key Mediators of S. aureus Virulence via the Global Modulation of Virulence Determinant Stability. Microbiology Open. 2(1): 18-34.


  • Carroll RK, Robison TM, Rivera FE, Davenport JE, Jonsson IM, Florczyk D, Tarkowski A, Potempa J, Koziel J, Shaw LN. (2012). Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus. Microbes & Infection. 14(11): 989-999.


  • Miller HK, Carroll RK, Burda WN, Krute CN, Davenport JE, Shaw LN. (2012). The ECF Sigma Factor, σS, Protects Against Both Cytoplasmic and Intracellular Stresses in Staphylococcus aureus. J Bacteriology. 194(16): 4342-4354.


  • Rivera F, Miller HK, Kolar SL, Stevens SM, Shaw LN. (2012). The Impact of CodY on Virulence Determinant Production in Community-Associated Methicillin Resistant Staphylococcus aureus. Proteomics. 12(2): 263-268.


  • Kolar SL, Nagarajan, V, Oszmiana A, Rivera FE, Miller HK, Davenport JE, Riordan JT, Potempa J, Barber DS, Koziel J, Elasri MO, Shaw LN. (2011). NsaRS is a Cell-Envelope-Stress Sensing Two-Component System of Staphylococcus aureus. Microbiology. 157(8): 2206-2219.


  • Kantyka T, Shaw LN, & Potempa J. (2011). Papain-Like Proteases of Staphylococcus aureus. Advances in Experimental Medicine and Biology. 712: 1-14.


  • Zielinska A, Beenken KE, Joo HS, Mrak L, Griffin LM, Luong TT, Lee CY, Otto M, Shaw LN, Smeltzer MS. (2011). Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator (sarA) on the Alpha Toxin Phenotype of Staphylococcus aureus. Journal of Bacteriology. 193(12): 2948-2958.


  • Ishihara K, Wawrzonek K, Shaw LN, Inagaki S, Miyamoto M, Potempa J. (2010). Dentipain, a Streptococcus-pyogenes-IdeS-protease homologue, is a novel virulence factor of Treponema denticola. Biological Chemistry. 391(9): 1047-55.


  • Beenken KE, Mrak LN, Griffin LM, Zielinska AK, Shaw LN, Rice KC, Horswill AR, Bayles KW, Smeltzer MS. (2010). Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS ONE. 5(5):e10790.


  • Koziel J, Maciag-Gudowska A, Mikolajczyk T, Bzowska M, Sturdevant DE, Whitney AR, Shaw LN, DeLeo FR, Potempa J.  (2009). Phagocytosis of Staphylococcus aureus by Macrophages Exerts Cytoprotective Effects Manifested by the Upregulation of Anti-apoptotic Factors. PLoS ONE. 4(4):e5210.


  • Shaw LN, Lindholm C, Prajsnar TK, Miller, HK, Brown, MC, Golonka E, Stewart GC, Tarkowski A, Potempa J. (2008). Identification and Characterization of σS, a novel component of the Staphylococcus aureus stress and virulence responses. PLoS ONE. 3(12):e3844.


  • Tsang LH, Cassat JE, Shaw LN, Beenken KE, Smeltzer MS. (2008). Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants. PLoS One. 3(10):33361


  • Johnson BT, Shaw LN, Nelson D, Mayo JA. (2008). Extracellular proteolytic activities expressed by Bacillus pumilus isolated from endodontic and periodontal lesions. Journal of Medical Microbiology. 57(5):643-651.


  • Lupa B, Lyon D, Shaw LN, Sieprawska-Lupa M, Wiegel J. (2008). Properties of the Reversible Non-oxidative Vanillate / 4-hydroxybenzoate Decarboxylase from Bacillus subtilis and the Corrected Annotation of its Genes. Canadian Journal of Microbiology. 54(1):75-81.


  • Kubica M, Guzik K, Koziel J, Zarebski M, Richter W, Gajkowska B, Golda A, Maciag-Gudowska A, Brix K, Shaw L, Foster TJ, Potempa J. (2008). A potential new pathway for Staphylococcus aureus dissemination: The silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. PLoS One. 3(1):e1409.


  • Shaw LN, Jonsson IM, Singh VK, Tarkowski A, Stewart GC. (2007). Inactivation of traP has no effect on the agr quorum-sensing system of virulence of Staphylococcus aureus. Infection and Immunity. 75(9): 4519-4527.


  • Golonka E, Potempa J, Travis J, Shaw LN. (2006). Poison-antidote systems in bacteria: the co-evolution of functional counterparts. Cellular & Molecular Biology. 52(4): 18-22.


  • Shaw LN, Aish J, Davenport JE, Brown, MC, Lithgow JK, Simmonite K, Crossley H, Travis J, Potempa J, Foster SJ. (2006). Investigations into σB–modulated regulatory pathways governing extracellular virulence determinant production in Staphylococcus aureus. Journal of Bacteriology. 188(17): 6070-6080.


  • Moon J, Shaw LN, Mayo J, Potempa J, Travis J. (2006). Isolation and Properties of Extracellular Proteinases of P. marneffei. Biological Chemistry. 387(7): 985-93.

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  • Potempa J, Golonka E, Filipek R, Shaw LN. (2005). Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases. Molecular Microbiology. 57(3): 605-10.


  • Shaw LN, Golonka E, Szmyd G, Foster SJ, Travis J, Potempa J. (2005). Cytoplasmic control of premature activation of a secreted protease zymogen: deletion of staphostatin B (SspC) in Staphylococcus aureus 8325-4 yields a profound pleiotropic phenotype. Journal of Bacteriology. 187(5): 1751-1762.


  • Calander AM, Jonsson IM, Kanth A, Arvidsson S, Shaw LN, Foster SJ, Tarkowski A. (2004). Impact of staphylococcal protease expression on the outcome of infectious arthritis. Microbes and Infection. 6(2): 202-206.


  • Shaw L, Golonka E, Potempa J, Foster SJ. (2004). The role and regulation of the extracellular proteases of Staphylococcus aureus. Microbiology. 150(1): 217-28.


  • Horsburgh MJ, Aish JL, White IJ, Shaw L, Lithgow JK, Foster SJ. (2002). sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. Journal of Bacteriology. 184(19): 5457-67.

DRUG DISCOVERY PAPERS

AT THE UNIVERSITY OF  SOUTH FLORIDA

PATHOGENESIS PAPERS

                  lAB   

  • Fleeman RM, Van Horn K, Barber M, Burda WN, Manetsch R, Shaw LN. Characterizing the Antimicrobial Activity of N2,N4-Disubstituted Quinazoline-2,4-Diamines Towards Multidrug Resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy. Accepted. DOI link: https://doi.org/10.1128/aac.00059-17.


  • Kirkpatrick C, Broberg C, McCool E, Lee WJ, Chao A, McConnell E, Pritchard D, Hebert M, Fleeman RM, Adams JA, Jamil A, Madera L, Strömstedt A, Goransson U, Liu Y, Hoskin D, Shaw LN, Hicks L. The ‘PepSAVI-MS’ pipeline for natural product bioactive peptide discovery. ACS Analytical Chemistry. 89(2): 1194-1201.


  • Li, Y, Bionda N, Fleeman RM, Wang H, Ozawa A, Houghten R, Shaw LN. (2016).Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a New Class of Antimicrobial Agents. Bioorganic & Medicinal Chemistry. 24(21): 5633-5638.

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  • Von Salm JF, Witowski C, Fleeman RM, McClintock J, Amsler C, Shaw LN, Baker BJ. (2016).Darwinolide, a new diterpene scaffold that inhibits MRSA biofilm from the Antarctic sponge Dendrilla membranosa. Organic Letters. 18(11): 2596-2599.


                  > This was the most read paper across all ACS Journals in 2016, with >90,000 reads.

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  • Battistini M, Mahajan S, Diaz D, Shaw LN, Merkler D. (2016). A Facile, Microwave-Assisted Synthesis of an Adenosine-Ribose Probe for Binding-Based Profiling of Nucleoside and Nucleotide-Binding Proteins. Current Microwave Chemistry. 3(2): 124-130.


  • Bionda N, Fleeman RM, Fuente-Nunez C, Rodriguez MC, Reffuveille F, Shaw LN, Pastar I, Davis SC, Hancock REW, Cudic P. (2016). Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities. European Journal of Medicinal Chemistry.108: 354-363.


  • Fleeman RM, LaVoi T, Santos RG, Morales A, Nefzi A, Welmaker GS, Medina-Franco J, Houghten RA, Giulianotti MA, Shaw LN. (2015). Combinatorial libraries as a tool for the discovery of novel antibacterial agents targeting the ESKAPE pathogens. Journal of Medicinal Chemistry. 58(8): 3340-3355.


  • Van Horn K, Burda WN, Shaw LN, Manetsch R. (2014). Antibacterial Activity of a Series of N2,N4-Disubstituted Quinazoline-2,4-Diamines. Journal of Medicinal Chemistry. 57: 3075-3093.


  • Bionda N, Fleeman RM, Shaw LN, Cudic P. (2013). Effect of Ester to Amide or N-methyl Amide Substitution on Membrane Depolarization and Antibacterial Activity of Novel Cyclic Lipopeptides. ChemMedChem. 8(8): 1394-1402.


  • Cormier R, Burda WN, Harrington L, Edlinger J, Kodigepalli KM, Thomas J, Kapolka R, Roma G, Anderson BE, Turos E, Shaw LN. (2012). Studies on the antimicrobial properties of N-Acylated ciprofloxacins. Bioorganic & Medicinal Chemistry Letters. 22(20): 6513-6520.


  • Niu Y, Padhee S, Wu H, Bai G, Harrington L, Burda WN, Shaw LN, Cao C, Cai J. (2012). Lipo-γ-AApeptides as a New Class of Potent and Broad Spectrum Antimicrobial Agents. J Med Chem. 55(8): 4003-4009.


  • Beau J, Mahid N, Burda WN, Harrington L, Shaw LN, Mutka T, Kyle DE, Barisic B, Van Olphen A, Baker BJ. (2012). Epigenetic Tailoring for the Production of Anti-infective Cytosporones from the Mangrove Endophyte Leucostoma persoonii. Marine Drugs. 10(4): 762-774.


  • Burda WN, Fields KB, Gill JB, Burt R, Shepherd M, Zhang XP, Shaw LN. (2012). Neutral Metallated and Meso-Substituted Porphyrins as Antimicrobial Agents Against Gram-Positive Pathogens. European Journal of Clinical Microbiology and Infectious Disease. 31(3): 327-335.


  • Niu Y, Padhee S, Wu H, Bai G, Harrington L, Burda WN, Shaw LN, Cao C, Cai J. (2011). Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. Chemical Communications. 47: 12197-12199.


  • Prosen KR, Carroll R, Burda WN, Krute CK, Bhattacharya B, Dao ML, Turos ET, Shaw LN. (2011). The Impact of Fatty Acids on the Antibacterial Properties of N-Thiolated β-Lactams. Bioorganic and Medicinal Chemistry Letters. 21(18): 5293-5.


  • Padhee S, Hu Y, Niu Y, Bai G, Wu H, Costanza F, West L, Harrington L, Shaw LN, Cao C, Cai J. (2011). Non-Hemolytic α-AApeptides as antimicrobial peptidomimetics. Chemical Communications. 47: 9729-9731.